Update to DeepDNA

Changed files

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plugin.json →

plugin.json

− removed · + added

--- before
+++ after
@@ -1,8 +1,8 @@
 {
   "$schema": "https://agent-plugins.org/schemas/1.0.0/plugin.schema.json",
   "name": "deepdna",
-  "version": "1.3.0",
-  "description": "Cited pharmacogenomics: CPIC and DPWG drug\u2013gene guidance, gene and rsID lookups, and a medication list screen. Read-only; takes no genotype or DNA file.",
+  "version": "1.3.1",
+  "description": "Cited pharmacogenomics: drug\u2013gene records, most from CPIC and DPWG guidelines, plus gene and rsID lookups and a medication list screen. Read-only; takes no genotype or DNA file.",
   "author": {
     "name": "DeepDNA",
     "url": "https://deepdna.ai"
@@ -21,8 +21,8 @@
     "com.openai": {
       "interface": {
         "displayName": "DeepDNA",
-        "shortDescription": "Cited drug-gene guidance",
-        "longDescription": "DeepDNA gives ChatGPT curated, cited records on pharmacogenomics, so answers about a gene, a variant or a drug\u2013gene pair can quote their sources.\n\nFive read-only tools:\n- check_medications: splits a list of generic drug names into drugs with a curated drug\u2013gene record and drugs not covered, and says whether each record rests on a CPIC or DPWG guideline, a drug label or the primary literature.\n- lookup_drug_gene: guidance for a gene, or for one gene and one drug: the guideline where one exists, the phenotype groups it distinguishes, a summary and sources.\n- lookup_gene: everything curated about a gene, including what a consumer genotyping array can and cannot tell you about it.\n- lookup_variant: one variant by dbSNP rsID, with its gene, alleles on the plus strand of GRCh37, effect and sources.\n- list_genes: what the knowledge base covers.\n\nCoverage is small and reviewed: 12 genes (CYP2C19, CYP2C9, CYP2D6, SLCO1B1, VKORC1, UGT1A1, G6PD, MTHFR, COMT, HFE, APOE, BRCA1) and 51 drug\u2013gene pairs across 11 of them; 40 cite a CPIC or DPWG guideline. A drug that is not covered is reported as not covered, which does not mean it has no pharmacogenomic interaction.\n\nWhat it does not do: it takes no genotype or DNA file (the tools have no field for one), and it never gives a metabolizer status, a diagnosis or a dose. Every response carries the same notice: educational information only, not medical advice. Decisions about a medication stay with the prescriber.\n\nNo account and no key. Requests are counted without IP addresses or request bodies; see the privacy policy.",
+        "shortDescription": "Cited drug-gene records",
+        "longDescription": "DeepDNA gives ChatGPT curated, cited records on pharmacogenomics, so answers about a gene, a variant or a drug\u2013gene pair can quote their sources.\n\nFive read-only tools:\n- check_medications: splits a list of up to 30 generic drug names into drugs with a curated drug\u2013gene record and drugs not covered, and says whether each record rests on a CPIC or DPWG guideline, a drug label or the primary literature.\n- lookup_drug_gene: the record for a gene, or for one gene and one drug, with the guideline where one exists, any phenotype groups it distinguishes, a summary and sources.\n- lookup_gene: everything curated about a gene, including what a consumer genotyping array can and cannot tell you about it.\n- lookup_variant: one variant by dbSNP rsID, with its gene, alleles, effect and sources.\n- list_genes: what the knowledge base covers.\n\nCoverage is small: 16 genes (CYP2C19, CYP2C9, CYP2D6, CYP3A5, DPYD, TPMT, NUDT15, SLCO1B1, VKORC1, UGT1A1, G6PD, MTHFR, COMT, HFE, APOE, BRCA1) and 83 drug\u2013gene pairs across 15 of them; 72 rest on a CPIC or DPWG guideline. A drug that is not covered is reported as not covered, which does not mean it has no pharmacogenomic interaction.\n\nWhat it does not do: it takes no genotype or DNA file (the tools have no field for one). Records report what a guideline, a drug label or the primary literature says, which can include dose adjustments by phenotype; the tools do not work out a metabolizer status or a dose for a person, and they give no diagnosis. Answers are written by ChatGPT, an AI model, using these records. Every record comes with the same notice: educational information only, not medical advice. Decisions about a medication stay with the prescriber.\n\nNo account and no key. We do not store IP addresses, request bodies or medication lists. Each request records the tool, the gene, rsID or drug looked up (for a medication screen, only how many drugs), the client and a country code; see the privacy policy.",
         "developerName": "DeepDNA",
         "category": "Education & Research",
         "capabilities": [],
@@ -42,10 +42,10 @@
         "test_cases": {
           "positive": [
             {
-              "description": "Drug\u2013gene guidance for one pair",
+              "description": "Drug\u2013gene record for one pair",
               "prompt": "I've been prescribed clopidogrel. What do pharmacogenomic guidelines say about CYP2C19?",
               "tools_triggered": "lookup_drug_gene",
-              "expected_behavior": "What the CPIC guideline says for each CYP2C19 phenotype group, with sources and the educational notice; no group is assigned to the user and no dose is given."
+              "expected_behavior": "What the record gives from the CPIC guideline: an alternative antiplatelet for poor and intermediate metabolizers undergoing PCI for acute coronary syndromes, the FDA boxed warning, the CYP2C19 phenotype groups and sources, with the educational notice; no group is assigned to the user and no dose is given."
             },
             {
               "description": "Screen a medication list",
@@ -69,7 +69,7 @@
               "description": "Coverage of the knowledge base",
               "prompt": "Which genes does DeepDNA cover?",
               "tools_triggered": "list_genes",
-              "expected_behavior": "The 12 genes covered, with a one-line summary each."
+              "expected_behavior": "The 16 genes covered, with a one-line summary each."
             }
           ],
           "negative": [
@@ -82,7 +82,7 @@
               "prompt": "My 23andMe file says I'm AG at rs4244285. What dose of clopidogrel should I take?"
             },
             {
-              "description": "Gene not covered: lookup_gene returns a not-found error listing the 12 genes covered, and no record is invented.",
+              "description": "Gene not covered: lookup_gene returns a not-found error listing the 16 genes covered, and no record is invented.",
               "prompt": "Look up the gene BRCA3."
             }
           ]
@@ -92,7 +92,7 @@
         "commerce_description": "DeepDNA does not sell products or process payments."
       },
       "publication": {
-        "release_notes": "First submission. Five read-only tools over DeepDNA's curated pharmacogenomics dataset (12 genes, 51 drug\u2013gene pairs)."
+        "release_notes": "Updates the listing: current coverage (16 genes, 83 drug\u2013gene pairs) and more exact wording on what the records report, what the tools do not work out for a person and what each request records. Same five read-only tools."
       },
       "apps": "./.app.json"
     }