skills/jinko-task-trial-data-scoping/evals/files/trial-scoping-use-cases.md

# Trial Scoping Use Cases

This file contains concise scientific briefs for testing `jinko-task-trial-data-scoping`. Each use case is limited to scientific context, trial registry/result scoping question, and problem framing.

## Use Case 1 - Treatment De-Escalation In Metastatic Lung Cancer

### Scientific Problem

Maintenance treatment intensity may be reducible in a front-line metastatic lung cancer regimen, but the risk is loss of clinical efficacy.

### Context Of Use

The team needs ClinicalTrials.gov registry and posted-results evidence to frame treatment de-escalation scenarios, preserve relevant efficacy endpoints, and understand how regimen changes may affect disease-control outcomes.

## Use Case 2 - Patient Population Selection In Acute Myeloid Leukemia

### Scientific Problem

Response variability in acute myeloid leukemia may depend on baseline molecular and cellular characteristics, making broad trial inclusion less efficient.

### Context Of Use

The team needs registered-trial evidence to understand eligibility criteria, baseline descriptors, response markers, and subgroup definitions that could support patient-selection hypotheses.

## Use Case 3 - Trial Design Efficiency In Atopic Dermatitis

### Scientific Problem

Atopic dermatitis has high phenotypic diversity, and treatment response can vary substantially across patient subgroups.

### Context Of Use

The team needs ClinicalTrials.gov evidence to frame biomarker-informed inclusion strategies, endpoint selection, and disease descriptors relevant to trial enrichment.

## Use Case 4 - Control-Arm Constraints In Rare Disease Trials

### Scientific Problem

Rare disease trials face recruitment limitations and ethical concerns around assigning scarce patients to control arms.

### Context Of Use

The team needs registry/result evidence to characterize natural history, standard-of-care outcomes, patient heterogeneity, endpoint variability, and control-arm availability in a small target population.

## Use Case 5 - Comparative Treatment Selection In EGFR-Mutated Lung Cancer

### Scientific Problem

Clinicians need comparative evidence across targeted treatment generations, but new head-to-head trials may be slow, expensive, or impractical.

### Context Of Use

The team needs ClinicalTrials.gov records and posted results on mutation-defined subgroups, treatment arms, progression endpoints, resistance patterns, and clinically relevant time-to-event endpoints.

## Use Case 6 - Treatment Regimen Optimization Before A Pivotal Trial

### Scientific Problem

An alternative regimen may be more effective or better tolerated than a classical regimen, but direct comparison in the pivotal trial may not be feasible.

### Context Of Use

The team needs registry/result evidence on regimen schedules, exposure context, efficacy endpoints, adverse effects, and treatment-duration effects.